Welcome to the Wang Group at USC

We are interested in harnessing the power of nature to create clinically useful drugs. We study the organisms that naturally produce biologically active molecules. Scientists in the lab have expertise in natural products isolation and characterization, synthetic organic chemistry, synthetic biology, fungal genetics, and genomics. An area of research in the Wang lab is astromycology where we study earth derived fungi in space. This research area has far reaching implications in human space exploration. 

 

 

Experimental Update SpaceX-CRS8:

05/26/16 The NASA-Micro10 was successfully launched to the ISS onboard SpaceX-CRS8 on April 8 and returned to Earth on May 11, 2016. Samples were recovered by the Micro 10 team from Cold Stowage on May 12, 2016 from the NASA transport aircraft at the Long Beach Airport. In this study we sent four different strains of A. nidulans to the International Space Station. Our goal is to understand the role of microgravity in natural product production in fungi. We hope to discover new natural products and/or new mechanisms of natural production biosynthesis regulation. We also believe this study will open up the opportunity to produce drugs in outer Space. We are grateful for the numerous press coverage please clink links below:

LA Times

Newsweek

Popular Science

Southern California Public Radio

Experimental Update SpaceX-CRS9:

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05/26/16 BRIC-Natural Products project also known as (CASIS-BRIC-NP) was launched onboard SpaceX-CRS9 on July 18, 2016. In this study we sent eight different species of fungi for the discovery of new natural products for agricultural and medicinal purposes. These organisms were isolated from the Chernobyl nuclear reactor disaster zone. Two of the species display radiotropism and grow towards radiation. Our goal for this project is to understand how these fungi utlize radiation and also to see if these organisms can make new compounds in space.  We are grateful for the numerous press coverage please click links below:

Popular Science

Motherboard

Members of the Wang group join the USC Bridge Undergraduate/High School Program (BUGS & BUGS Jr)

Bethany Chen; ada li; Stephanie Loekman; Clay wang; Joy Ahn Summer 2016

Bethany Chen; ada li; Stephanie Loekman; Clay wang; Joy Ahn Summer 2016

Ting Wei (Kevin) Chang, Justin Nakama, elizabeth (Bethany) Cheng; Clay Wang Summer 2017

Ting Wei (Kevin) Chang, Justin Nakama, elizabeth (Bethany) Cheng; Clay Wang Summer 2017

Wang group lab manager Johannes van Dijk wins the 2017 Krown Fellowship

Johannes who goes by Jan as been awarded the top Ph.D. student award at the USC School of Pharmacy. Hard work and dedication does pay off.

Wang group member Weiwen Sun wins the 2016 Krown Fellowship

Weiwen has continued the long tradition of the Wang group in winning the top Ph.D. student award at the USC School of Pharmacy. Congratulations.

On a lighter note:

The new Star Trek series "Star Trek Discovery" will have an astromycologist, Lt. Stamets onboard as Starfleet Science Officer. The series starts Sept 2017.

 

Funding news:

1/16/17 The Wang was recently awarded a grant from National Institutes of Allergies and Infectious Diseases to develop new antifungal agents.

11/1/16 Prof. Nancy Keller, Dr. Venkateswaran, and my lab received a  NASA space biology grant related to the analysis of filamentous fungi isolated from the ISS. 

Publication news

Our first two papers related to our Space research program have been published in Genome Announcements and mSpheres. We published the Draft Genome sequence of two Aspergillus fumigatus strains isolated from the International Space Station. In the second paper we analyzed the two strains via multi-omic approaches.

FYI

PI Clay Wang has been appointed Department Chair of Pharmacology and Pharmaceutical Sciences at USC School of Pharmacy

 

 

 

 

Research Supported by

National Institutes of Health

National Science Foundation

Department of Defense

Department of Energy

National Aeronautics and Space Administration

Center for the Advancements of Science in Space

Joint Genome Institute