Welcome to the Wang Group at USC
We are interested in harnessing the power of nature to create clinically useful drugs. We study the organisms that naturally produce biologically active molecules. Scientists in the lab have expertise in natural products isolation and characterization, synthetic organic chemistry, synthetic biology, fungal genetics, and genomics. An area of research in the Wang lab is astromycology where we study earth derived fungi in space. This research area has far reaching implications in human space exploration.
Find out what we do in the Wang group. Let Jan tell you his project
Experimental Update SpaceX-CRS8:
05/26/16 The NASA-Micro10 was successfully launched to the ISS onboard SpaceX-CRS8 on April 8 and returned to Earth on May 11, 2016. Samples were recovered by the Micro 10 team from Cold Stowage on May 12, 2016 from the NASA transport aircraft at the Long Beach Airport. In this study we sent four different strains of A. nidulans to the International Space Station. Our goal is to understand the role of microgravity in natural product production in fungi. We hope to discover new natural products and/or new mechanisms of natural production biosynthesis regulation. We also believe this study will open up the opportunity to produce drugs in outer Space. We are grateful for the numerous press coverage please clink links below:
05/26/16 BRIC-Natural Products project also known as (CASIS-BRIC-NP) was launched onboard SpaceX-CRS9 on July 18, 2016. In this study we sent eight different species of fungi for the discovery of new natural products for agricultural and medicinal purposes. These organisms were isolated from the Chernobyl nuclear reactor disaster zone. Two of the species display radiotropism and grow towards radiation. Our goal for this project is to understand how these fungi utlize radiation and also to see if these organisms can make new compounds in space. We are grateful for the numerous press coverage please click links below:
Congratulations to CJ
06/28/18 Former Wang group Ph.D. student Dr. Chun Jun (CJ) Guo has accepted a tenured track Assistant Professor position at Weill Cornell Medical School in New York City.
Wang group members receive their Ph.D. and M.S. degrees from USC:
05/11/18 Three members of the Wang group (Kevin Lin, Jillian Romsdahl, and Johannes van Dijk) received their Ph.D. degrees. Yi En Liao received her M.S. degree. Big congratulations on their hard work and journey.
Members of the Wang group join the USC Bridge Undergraduate/High School Program (BUGS & BUGS Jr)
Wang group members accepted to USC undergrad program:
04/10/18 Three members of our high school summer research program (Kara Lee, Bethany Chen and Elizabeth Cheng) have been accepted to USC and will join the class of 2022. The acceptance rate at USC for 2018 was just 13 percent, the lowest ever in our history. They were selected from 64,000 applicants.
Wang group attends the European Conference in Fungal Genetics ECFG14 and Asperfest 15 in Haifa, Israel:
08/11/18 Two papers accepted in the same week. One paper published in FGB describes our work on the acetylarantin pathway in A. terreus. A second paper in Org Lett. describes our efforts in investigating NRPS-like genes.
Michelle Grau wins Best Poster Awards at ECFG14 and Asperfest 15:
Congrats to Kevin Lin and Yi En Liao in successfully defending their theses.
Wang group lab manager Johannes van Dijk wins the 2017 Krown Fellowship:
Johannes who goes by Jan has been awarded the top Ph.D. student award at the USC School of Pharmacy. Hard work and dedication does pay off.
Wang group member Weiwen Sun wins the 2016 Krown Fellowship:
Weiwen has continued the long tradition of the Wang group in winning the top Ph.D. student award at the USC School of Pharmacy. Congratulations.
On a lighter note:
The new Star Trek series "Star Trek Discovery" will have an astromycologist, Lt. Stamets onboard as Starfleet Science Officer. The series starts Sept 2017.
1/16/17 The Wang was recently awarded a grant from National Institutes of Allergies and Infectious Diseases to develop new antifungal agents.
11/1/16 Prof. Nancy Keller, Dr. Venkateswaran, and my lab received a NASA space biology grant related to the analysis of filamentous fungi isolated from the ISS.
Our first two papers related to our Space research program have been published in Genome Announcements and mSpheres. We published the Draft Genome sequence of two Aspergillus fumigatus strains isolated from the International Space Station. In the second paper we analyzed the two strains via multi-omic approaches.
PI Clay Wang has been appointed Department Chair of Pharmacology and Pharmaceutical Sciences at USC School of Pharmacy